AE2 is not perfect and there are some small issues which might occur when using the mod. Some of these quirks can be avoided as long as you power your network and keep within the channel limits of each cable.
Sometimes it takes a little while for AE2 to process how many machines are on a certain cable, channel updates can take a few seconds depending on the size of your network. TTB can happen when you add too many machines to a cable, at first everything will be online but if you don't stop and watch to see if everything stays online the whole section could go offline. This does not always happen quickly and sometimes takes a few seconds, Make sure you are within the limits of your cable.